In vitro in vivo drug metabolism describes two separate types of test. Here ‘in vitro’ means literally ‘in glass’ or ‘in the test tube’. In other words here then the drug metabolism is tested in some form of test tube. On the other hand the ‘in vivo’ aspect of the in vitro in vivo drug metabolism means ‘in the organism’ which means it is tested inside a subject. The primary site of drug metabolism is the liver.
Meanwhile pharmacokinetics is something slightly different but very related. This is the study of how the body treats the drug in its various forms and its stages as it travels throughout the body. This then involves bioanalysis in order to establish how long it takes for the medication to be broken down, distributed throughout the body, and eventually excreted. Altering the makeup of the medication can then alter how long it takes to be broken down, how it is used in the body and how it is excreted. This might also lead to changes in the delivery system. Pharmacokinetics is distinct from in vitro in vivo drug metabolism as it not only measures how the body uses the active agent, but the journey of the medication from its ingestion to its end.
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