Our Services

In Vivo Drug Metabolism & ADME

In Vivo Drug Metabolism & ADME

In addition to traditional mouse PK studies, BRI also offers dried blood spot (DBS) sampling technique to allow  serial sampling collection of whole blood from a mouse over the entire PK profile. The same technique also applies in xenograft mouse models  allowing simultaneous determination of efficacy and PK  within the same animal.

RAPID IN VIVO PK SCREENING

In vivo rapid oral exposure and plasma T1/2 PK in mouse or rats

– Single oral dose
– Plasma exposure at 1 hr and 1.5 hr
– Plasma T1/2 at 6 hr and 8 hr
– LC/MS/MS plasma assay
– Plasma oral AUC data within one-week

OTHER IN VIVO DMPK & ADME STUDIES

– Rapid PK using dried-blood spot method
– Pharmacokinetics & oral bioavailability studies
– Urine, bile and feces drug and metabolite excretion mass balance
– 14C & 3H tissue distribution mass balance
– CNS cannulated rat model for collection of CSF
– Determination of major routes of elimination

CHEMISTRY SUPPORT

– Evaluation of drug substance True Solution Solubility™ in aqueous buffers used for safety pharmacology and toxicology studies
– Verification of dose material label claim concentrations by HPLC or LC/MS
– Dose materials stability and homogeneity